Familial occurrence of mitral valve prolapse in X-linked muscular dystrophy.
نویسندگان
چکیده
A high incidence of mitral valve prolapse (MVP) has been reported in patients with X-linked Duchenne muscular dystrophy. In our study MVP was present in six of 22 Duchenne dystrophy cases (27%) followed in the Maryland General Hospital Muscular Dystrophy Clinic. In addition, seven carriers of Duchenne and X-linked benign (Becker) dystrophy had evidence of MVP. Autosomal dominant transmission of MVP was present in four families. The unusually high prevalence of MVP in families with X-linked muscular dystrophy may have potential value in the recognition of the carrier trait.
منابع مشابه
Degenerating heart valves: fill them up with filamin?
Myxoid valvular heart dystrophies are a frequent cause of valvular diseases. They affect approximately 3% of the population and are the most common cause of isolated mitral regurgitations that require surgical repair.1,2 These valvular diseases are a heterogeneous group of disorders and include isolated nonsyndromic valvular diseases, such as idiopathic mitral valve prolapse and the X-linked my...
متن کاملClinical characteristics of a familial inherited myxomatous valvular dystrophy mapped to Xq28.
OBJECTIVES The purpose of this study was to describe the phenotypic characteristics of an inherited myxomatous valvular dystrophy mapped to Xq28. BACKGROUND Myxomatous valve dystrophies are a frequent cause of valvular diseases, the most common being idiopathic mitral valve prolapse. They form a group of heterogeneous diseases difficult to subclassify. The first mapping of the gene for a myxo...
متن کاملMyotonic dystrophy, mitral valve prolapse, and cerebral embolism.
CARDIAC abnormalities are the rule in hereditary myopathy, and myotonic dystrophy (MD) is no exception. Conduction disturbances are most common, manifested by first degree atrioventricular block,intraventricular conductive defect, and by evidence of disease in the entire conductive system on His bundle electrogram. The association between mitral valve prolapse (MVP) and MD has been reported as ...
متن کاملDystrophic degeneration of papillary muscle and ventricular myocardium. A basis for mitral valve prolapse in Duchenne's muscular dystrophy.
The hearts of three children who died with Duchenne's progressive muscular dystrophy and features of mitral valve prolapse were examined to find if the valve disorder arose from cardiomyopathy due to the primary disease or from dystrophic changes in th mitral valve itself. Gross, histologic and ultrastructural features of mitral valve annulus, anterior and posterior leaflets, chordae tendineae,...
متن کاملMarcus-gunn phenomenon with- mitral valve prolapse
Marcus-gunn phenomenon is a congenital and sometimes hereditary anomaly, in which a ptotic eyelid retracts momentarily when the mouth is open, or the jaw is moved. These associated movements attributed to abnormal connections between the central mechanisms innervating the pterygoid and elevator muscles. Sometimes this anomaly is associated with dual,s retraction syndrome, duplex kindneys and ur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 59 6 شماره
صفحات -
تاریخ انتشار 1979